If you are interested in examining how exposure to pollutants influences neurodevelopment and whether these exposures interact with genetic variants associated with psychiatric disease, please get in touch with Daniel Barabasi. The plan is for you to be a key player of our cool team that comprises Daniel Barabasi, Marie-Abele Bind (biostatistician at MGH/HMS), and Florian Engert. You will use sensitive behavioral testing tools we have developed and tested for larval zebrafish and statistical models that permit us to quantify the effect of pollutants alone and in combination with potential genetic sensitizers. By combining these 21st century toxicology testing, behavioral assays, and statistical tools, the collaborative effort should lay the groundwork to quantify the magnitude and uncertainty of the neural effects of early life environmental exposures according to genetic profiles, and might therefore suggest environmental policy changes that protect susceptible subpopulations.

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